Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy
- Creator: van Hummel, Annika , Taleski, Goce , Sontag, Jean-Marie , Feiten, Astrid Feentje , Ke, Yazi D. , Ittner, Lars M. , Sontag, Estelle
- Resource Type: journal article
- Date: 2023
Ppp2r2aKnockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55 alpha, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development
- Creator: Panicker, Nikita , Coutman, Melody , Lawlor-O'Neill, Charley , Kahl, Richard G. S. , Roselli, Severine , Verrills, Nicole M.
- Resource Type: journal article
- Date: 2020
Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
- Creator: Nader, Cassandra P. , Cidem, Aylin , Verrills, Nicole M. , Ammit, Alaina J.
- Resource Type: journal article
- Date: 2019
Protein phosphatase 2A: more than a passenger in the regulation of epithelial cell-cell junctions
- Creator: Schuhmacher, Diana , Sontag, Jean-Marie , Sontag, Estelle
- Resource Type: journal article
- Date: 2019
The functional role of PPP2R2A in luminal breast cancer
- Creator: Mannan, Abdul
- Resource Type: thesis
- Date: 2019
The role of protein phosphatase 2A in Alzheimer’s disease pathogenesis
- Creator: Hoffman, Alexander
- Resource Type: thesis
- Date: 2019
TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis
- Creator: Collison, Adam M. , Li, Junyao , de Siqueira, Ana Pereira , Lv, Xuejiao , Toop, Hamish D. , Morris, Jonathan C. , Starkey, Malcolm R. , Hansbro, Philip M. , Zhang, Jie , Mattes, Joerg
- Resource Type: journal article
- Date: 2019
Protein phosphatase 2A and tau: an orchestrated 'Pas de Deux'
- Creator: Taleski, Goce , Sontag, Estelle
- Resource Type: journal article
- Date: 2018
Functional importance of PP2A regulatory subunit loss in breast cancer
- Creator: Watt, Lauren F. , Panicker, Nikita , Mannan, Abdul , Copeland, Ben , Kahl, Richard G. S. , Dun, Matthew D. , Young, Barbara , Roselli, Severine , Verrills, Nicole M.
- Resource Type: journal article
- Date: 2017
The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: a triple threat in the regulation of the neuronal cytoskeleton
- Creator: Hoffman, Alexander , Taleski, Goce , Sontag, Estelle
- Resource Type: journal article
- Date: 2017
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors
- Creator: Smith, Amanda M. , Dun, Matthew D. , Toop, Hamish , Lock, Richard B. , Powell, Jason A. , Thomas, Daniel , Guthridge, Mark A. , Moore, Andrew , Ashman, Leonie K. , Skelding, Kathryn A. , Enjeti, Anoop , Verrills, Nicole M. , Lee, Erwin M. , Harrison, Celeste , Kahl, Richard , Flanagan, Hayley , Panicker, Nikita , Mashkani, Baratali , Don, Anthony S. , Morris, Jonathan
- Resource Type: journal article
- Date: 2016
Immunoregulatory therapies for inflammatory diseases
- Creator: Monogar, Prema Mono Nair
- Resource Type: thesis
- Date: 2016
TLR2 ligation induces corticosteroid insensitivity in A549 lung epithelial cells: anti-inflammatory impact of PP2A activators
- Creator: Rahman, Md. Mostafizur , Prabhala, Pavan , Rumzhum, Nowshin N. , Patel, Brijeshkumar S. , Wickop, Thomas , Hansbro, Phillip M. , Verrills, Nicole M. , Ammit, Alaina J.
- Resource Type: journal article
- Date: 2016
TRAIL deficiency and PP2A activation with salmeterol ameliorates egg allergen-driven eosinophilic esophagitis
- Creator: Sokulsky, Leon A. , Collison, Adam M. , Nightingale, Scott , Le Fevre, Anna , Percival, Elizabeth , Starkey, Malcolm R. , Hansbro, Philip M. , Foster, Paul S. , Mattes, Joerg
- Resource Type: journal article
- Date: 2016
Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin
- Creator: Rahman, Md. Mostafizur , Rumzhum, Nowshin N. , Morris, Jonathan C. , Clark, Andrew R. , Verrills, Nicole M. , Ammit, Alaina J.
- Resource Type: journal article
- Date: 2015
Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice
- Creator: Sontag, Jean-Marie , Wasek, Brandi , Taleski, Goce , Smith, Josephine , Arning, Erland , Sontag, Estelle , Bottiglieri, T
- Resource Type: journal article
- Date: 2014
Targeting PP2A activation as a novel therapeutic strategy for receptor tyrosine kinase driven leukaemia
- Creator: Smith, Amanda Melanie
- Resource Type: thesis
- Date: 2014
Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells
- Creator: Sontag, Jean-Marie , Nunbhakdi-Craig, Viyada , Sontag, Estelle
- Resource Type: journal article
- Date: 2013
PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9
- Creator: Bradbury, Peta , Mahmassani, Maha , Zhong, Jessie , Turner, Kylie , Paul, Andre , Verrills, Nicole M. , O'Neill, Geraldine M.
- Resource Type: journal article
- Date: 2012
Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress
- Creator: Tay, K. H. , Jin, L. , Zhang, X. D. , Tseng, H. - Y. , Jiang, C. C. , Ye, Y. , Thorne, R. F. , Liu, T. , Guo, S. T. , Verrills, N. M. , Hersey, P.
- Resource Type: journal article
- Date: 2012